How cam the many cells in an individual be very diffrent from one another, eventhough they are all descended from a single cell and thus have essentially identical genetic instructions?

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How cam the many cells in an individual be very diffrent from one another, eventhough they are all descended from a single cell and thus have essentially identical genetic instructions?

Biology
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All cells contain every gene, but as a cell differentiates (for example a skin cell) it "shuts off" all genes unrelated to being a skin cell. Stem cells are cells that have not yet shut off their genes yet.
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