A community for students.

Here's the question you clicked on:

55 members online
  • 0 replying
  • 0 viewing


  • 5 years ago

if the action potential is always the same in size and shape, why in the "giant squid's axon" experiment ,carried out by Hodgkin and Huxley, the peak of the action potential depends on the Na+ concentration in extracellular solution ?

  • This Question is Closed
  1. Owlfred
    • 5 years ago
    Best Response
    You've already chosen the best response.
    Medals 0

    Hoot! You just asked your first question! Hang tight while I find people to answer it for you. You can thank people who give you good answers by clicking the 'Good Answer' button on the right!

  2. anonymous
    • 5 years ago
    Best Response
    You've already chosen the best response.
    Medals 0

    Normally extracellular Na is 142mEq/L and K is 4mEq/L intracellular Na is mEq/L and K is 140mEq/L. This intracellular Potassium is responsible for the intracellular negativity which is maintained around -90millivolts by the active Sodium-Potassium Pump. An Action Potential is associated with rapid changes in the membrane potential moving towards positivity and upon reaching a threshold shooting up to 40milliovolts. This shooting up is facilitated by voltage gated sodium channel. when the voltage is somewhere between -70 and -50 millivolts this gate opens permitting Na ions to pour into the cell. The time for which this gate is kept open is very limited . Immediately the gate closes and Repolarisation starts. Under such a situation the extracellular Na levels if low naturally cannot pour in to rise the action potential peak. Alternatively high levels of extracellular Na can make more Na move in within given gate time resulting in Higher action potential peak levels

  3. Not the answer you are looking for?
    Search for more explanations.

    • Attachments:

Ask your own question

Sign Up
Find more explanations on OpenStudy
Privacy Policy

Your question is ready. Sign up for free to start getting answers.

spraguer (Moderator)
5 → View Detailed Profile

is replying to Can someone tell me what button the professor is hitting...


  • Teamwork 19 Teammate
  • Problem Solving 19 Hero
  • You have blocked this person.
  • ✔ You're a fan Checking fan status...

Thanks for being so helpful in mathematics. If you are getting quality help, make sure you spread the word about OpenStudy.

This is the testimonial you wrote.
You haven't written a testimonial for Owlfred.