ORGANIC: why does vanillin direct to the 5 spot upon bromonation (5-bromo-vanillin) instead of the 2 or 6 spot?
Stacey Warren - Expert brainly.com
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there are 2 o/p directors and only 1 meta director so?
Well it's gonna wanna go ortho to the -OH group because hydroxyl groups are very strong activators. In the 5 spot it is also meta to the -CHO group.
It's probably not gonna want to go to the 2 spot because even though the -OCH3 group is a strong o/p director there's too much steric hindrance with the -CHO group.
Putting it at the 6 spot would put it ortho to the -CHO group (which doens't make sense because that group is meta directing), para to the -OCH3 group and meta to the hydroxyl group (doesn't make sense because that group is o/p directing)