A community for students.

Here's the question you clicked on:

55 members online
  • 0 replying
  • 0 viewing


  • 4 years ago

why is aged cell or organ more vulnerable to pathology?

  • This Question is Closed
  1. anonymous
    • 4 years ago
    Best Response
    You've already chosen the best response.
    Medals 0

    I'd wager that one reason is by the accumulation of mutation. From a perspective of time - a cell or organ that is older simply has had more time for damaging mutagens and UV radiation to take their toll on the DNA. It's more probable for an older cell or organ to have such mutations occur in a vital part of the genome, which may render defenseless against certain pathogens. One would think that such mutations would be selected against, and weeded out given a decent amount of time. This is not always the case. In the context of an organism - evolutionary pressures are weaker as the organism gets older, because it also becomes less likely to reproduce. Detrimental mutations build-up simply because they are no longer passed on, and thus cannot be selected against. These mutations, which manifest themselves when the organism is old, persist in the gene pool. This approach incidentally comes from Medawar's proposed theory on why we age.

  2. anonymous
    • 4 years ago
    Best Response
    You've already chosen the best response.
    Medals 0

    kma230 gave a very good answer. I'd like to speculate that an aged organ has less ability to repair itself due to lower numbers of stem cells.

  3. Not the answer you are looking for?
    Search for more explanations.

    • Attachments:

Ask your own question

Sign Up
Find more explanations on OpenStudy
Privacy Policy

Your question is ready. Sign up for free to start getting answers.

spraguer (Moderator)
5 → View Detailed Profile

is replying to Can someone tell me what button the professor is hitting...


  • Teamwork 19 Teammate
  • Problem Solving 19 Hero
  • You have blocked this person.
  • ✔ You're a fan Checking fan status...

Thanks for being so helpful in mathematics. If you are getting quality help, make sure you spread the word about OpenStudy.

This is the testimonial you wrote.
You haven't written a testimonial for Owlfred.