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yukitou
 2 years ago
Is there any modulating factor affecting the tightness of tight junction?
yukitou
 2 years ago
Is there any modulating factor affecting the tightness of tight junction?

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kma230
 2 years ago
Best ResponseYou've already chosen the best response.1I'm not sure of an exact factor affecting the tightness, but I do recall that the tightness varies with the location (and therefore function) of the tight junction, I believe. In the kidney tubules, the tight junctions are much more resistant to Na+ diffusion, whereas in the intestines, they are more leaky, if I recall correctly. Hope that helps a bit!

yukitou
 2 years ago
Best ResponseYou've already chosen the best response.0Thanks @kma230. I knew that the tightness can vary because of the location. I'm also curious to know if is there any chemical that can affect the tightness.

tafkas77
 2 years ago
Best ResponseYou've already chosen the best response.0Well, chemical factors being released internally to the blood stream may regulate the tightness. An example of such a chemical would be Phospholipase C (PLP).
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