Is there any modulating factor affecting the tightness of tight junction?
Stacey Warren - Expert brainly.com
Hey! We 've verified this expert answer for you, click below to unlock the details :)
At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga.
Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus.
Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat.
I got my questions answered at brainly.com in under 10 minutes. Go to brainly.com now for free help!
I'm not sure of an exact factor affecting the tightness, but I do recall that the tightness varies with the location (and therefore function) of the tight junction, I believe.
In the kidney tubules, the tight junctions are much more resistant to Na+ diffusion, whereas in the intestines, they are more leaky, if I recall correctly. Hope that helps a bit!
Thanks @kma230. I knew that the tightness can vary because of the location. I'm also curious to know if is there any chemical that can affect the tightness.
Well, chemical factors being released internally to the blood stream may regulate the tightness. An example of such a chemical would be Phospholipase C (PLP).