Read this excerpt of Lady Macbeth’s famous speech from Act V of Macbeth:
Out, damned spot! Out, I say! One: two: why then ‘tis time to do’t. Hell is murky. Fie, my lord, fie! A soldier and afeard? What need we fear who knows it, when none can call our pow’r to accompt? Yet who would have thought the old man to have had so much blood in him?
Lady Macbeth’s actions and disturbed sleep are evidence of her
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steadfast support of her husband.
hopes of tricking the doctor and the gentlewoman.
guilt and mental fragility.
charismatic and regal personality.
guilt and mental fragility - "Out, damned spot!" signifies Lady MacBeth's attempt to rid herself of the figurative "blood on her hands" as a result of goading her husband MacBeth into murdering "the old man" King Duncan so MacBeth can aspire to the throne.