After giving her dog a bath, a young girl suddenly died. The flea dip she was using on the dog contains a chemical called rotenone which inhibits the function of an enzyme that oxidizes NADH to NAD+. Her autopsy revealed massive cell death in her internal organs and damage to her mitochondria. The levels of NAD+ were very low and the levels of NADH were very high in her mitochondria. What part of cellular respiration was affected by the rotenone (1 pt)? How could this have led to her death (1 pt)?
MIT OCW Biology
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Rotenone is an inhibitor of complex 1 NADH DESHYDROGENASE...so NADH couldnot been oxidized back...thats why the acumulation of NADH in mitochondria..respiratory chain stopped...