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Frostbite
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A picture I would like to share with the biology group: Some of the ideas about our beloved membranes
 one year ago
 one year ago
Frostbite Group Title
A picture I would like to share with the biology group: Some of the ideas about our beloved membranes
 one year ago
 one year ago

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InYourHead Group TitleBest ResponseYou've already chosen the best response.0
WHAT the flip is this?
 one year ago

Frostbite Group TitleBest ResponseYou've already chosen the best response.0
THIS is how we "should" describe a membrane :P
 one year ago

TranceNova Group TitleBest ResponseYou've already chosen the best response.0
You make me wish I knew more about membranes. Can you describe your diagram a little more? :D
 one year ago

SchoolSlacker Group TitleBest ResponseYou've already chosen the best response.0
That I would like to learn.
 one year ago

Frostbite Group TitleBest ResponseYou've already chosen the best response.0
Sure can TranceNova :D ****************************************** ***************WARNING***************** ****************************************** *****Mathematics and Physics ahead***** ****************************************** First a minor history: It is not unusual that the lipid bilayer of a membrane can be modeled as a twodimensional surface embedded in threedimensinal euclidean space. In this kind of modeling, proteins or other entities that can bind to the membrane as represented by solid particles that impose deformations/curvatures in the surface. Acording to physics/chemicalphysics the behavior of the membrane under deformations can be predicted by knowing the change in energy. Wolfram Helfrich suggested in 1973 that the deformation energy of a thin fluid membrane as a sum of three energies: The bending energy, the frame energy and the energy as result of change in gaussian curvature. The bending energy: \[E _{bending}=\frac{ \kappa A }{ 2 }(HH _{0})\] The frame energy: \[E _{frame }=\sigma(AA _{flat})\] The gaussian energy: \[E _{graussian}=\kappa \prime K A\] Many of the equations shown the diagram can be deduced from the three equations here. But now to the main point: A description of the diagram. The diagram show what kind of models that works within property of the change in time (change in time > change in energy (perhaps)) and the lenght scale/zoom. Depending on what we research in, where a membrane is involved, we need to be aware on this concept becuase the model we use make a limit to fx only see the initial energy of the membrane insted of the change over time.
 one year ago

agreene Group TitleBest ResponseYou've already chosen the best response.0
I do Computational Biophysics & Biochemistry, although I don't model cell membranes, this is more or less how I view DNA and Ligand interactions ;) It's always fun to see the math behind the structures.
 one year ago

SchoolSlacker Group TitleBest ResponseYou've already chosen the best response.0
This is very interesting, thanks for sharing. :)
 one year ago

rahulchatterjee Group TitleBest ResponseYou've already chosen the best response.0
what those parameters refer to??
 one year ago

Frostbite Group TitleBest ResponseYou've already chosen the best response.0
@rahulchatterjee If you are thinking about the equations i set up the in aditional answer it is as follow: Equation 1: H = C1 + C2 where the following is: C1 and C2 are the principal curvatures when the membrane is modeled as a surface embedded in 3dimensional space and H0 is the spontaneous curvature of the membrane, κ is the bending rigidity, A is the surface area of a piece of the membrane which is denoted as a domain. Equation 2: σ is the frame tension and Aflat is the projected area of the membrane domain area A onto the flat plane. Equation 3: κ' is the splay modulus and K is the Gaussian curvature over the membrane domain with area A.
 one year ago

dusty Group TitleBest ResponseYou've already chosen the best response.0
thats cool(:
 one year ago

Frostbite Group TitleBest ResponseYou've already chosen the best response.0
Else if you want to know more about it read about the Helfrich Hamiltonian Membrane
 one year ago
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