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SomE hormones don't require an integral membrane protein receptor, why... I know it is because hormone is lipid soluble.... Can anyone please explain me how hormone is lipid soluble or elaborate more on the answer please... Thanks

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Like dissolves like. Charged signalling molecules like peptides cannot pass through membranes because they are soluble in water (able to diffuse through the extracellular fluid) but are unable to diffuse through the hydrophobic cell membrane. Remember that the cell membrane is made up of uncharged, hydrophobic molecules that water soluble things cannot diffuse through. Steroid hormones are pretty much all based on cholesterol - similar in structure, often cholesterol molecules go into their synthesis. Cholesterol and steroid hormones are uncharged, lipid soluble molecules. Just like the molecules that make up the cell membrane that keeps the polar molecules like water and peptides out. So they diffuse right on through the membrane into the cells. Hope that's helpful...?
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