Bacteria have many ways to survive, including developing mutations that provide them with a resistance to antibiotic medications. The standard practice of doctors is to administer a single antibiotic medication at a time to their patients. However, active infections are sometimes treated with a combination of several antibiotics given simultaneously to reduce the chances of bacteria developing antibiotic resistance. Why would giving multiple antibiotics at once be less likely to create a population of resistant bacteria?
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A. While bacteria may be able to survive the destruction of one of their genes, it is less likely that they would be able to survive the destruction of several genes at the same time.
B. Most bacteria would not develop all the mutations needed to resist the attack of multiple antibiotics given at the same time.
C. Giving one antibiotic at a time would allow the bacteria enough time to tailor the correct mutations they needed to resist all antibiotics they might come in contact with in the future.
D. A bacterium would need to have a mutation caused by insertion or deletion of a sequence, which is much less likely to occur than a base pair substitution, in order to survive several antibiotics at a time.
@agentscape I think it is D but I am not sure can you help me
I'm sorry,but i don't know the answer to this question !
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I think is B. Different bacteria strains in same species can be resistant to different drug. Some can be resistant to drug A, some is to drug B, and so on. If you only give drug A only, those that is resistant to drug A will survive and you will have most of the strains that are resistant to drug A. If you then give drug B because drug A is not effective for some strains, some strain will die but those that survive will have mutation so they have drug B resistant. Now you have bacteria that are both resistant to drug A and B because they have time to develop resistant to each of the drug. But if you give both drug A and B at the same time, the drug A can kill those that are susceptible to drug A and drug B can kill those susceptible to drug B.
Why not A: I don't think antibiotic can destroy gene. Antibiotic interferes bacterial growth or make bacteria to lyse. This can be done in several ways: interfere folate synthesis(so that no folic acid is available for DNA repair), disrupt the peptidoglycan cell wall synthesis (so that the bacteria lyses), bind to bacteria ribosome to inhibit protein synthesis and so on.
Why not C: Bacteria mutates due to selection pressure such as antibiotic. If no selection pressure, they won't mutate and evolve because they are still in comfort zone.
Why not D: Treponema pallidum bacteria have point mutation, therefore they are resistant to macrolide. So bacteria mutation does not have to be insertion or deletion. Also, mutations occur as DNA is being replicated. For every 10^9 dNTP added, there will be one error. If the bacteria species has fast doubling time, they will be faster to be resistant to drug.
I hope this helps. Correct me if i am wrong.