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gerryliyana

What is the usefulness of MODELING GENE EXPRESSION ????

  • one year ago
  • one year ago

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  1. gerryliyana
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    • one year ago
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  2. gerryliyana
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    Guys.., do you have any ideas??

    • one year ago
  3. Frostbite
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    Question: do I have to read it all?

    • one year ago
  4. gerryliyana
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    recommended :)

    • one year ago
  5. Frostbite
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    However the usefulness I can see as an important becuase if you want to do some kind of "gene kinetics" I see you use diffrential eqautions so you try to explain a change. Prob over time (without reading the full paper), this also give an idea of the flow of DNA replication mRNA translation and so on.

    • one year ago
  6. Frostbite
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    You could think like that... however for so big a system it most be a damn good model?

    • one year ago
  7. Frostbite
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    But what would you think?

    • one year ago
  8. Frostbite
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    And when it come to usefullness... well you can determine the flow of proteins? :)

    • one year ago
  9. Frostbite
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    @blues

    • one year ago
  10. gerryliyana
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    Thank you! :) .., How do I apply it ? for example, how to determine the value of protein concentration at any given time., ? and so on.,

    • one year ago
  11. Frostbite
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    Well that is the quite hard part... You need to read the artical part by part then, analyzing the equations and find out what values you may know for an example: \[\frac{ dP }{ dt }=Lr-Up\] (equation 1) Might be a bit hard to use becuase we then need to know translational constants, mRNA concentrations, degradation rates of proteins and ofcause the protein concentration it self.

    • one year ago
  12. Frostbite
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    But I can see he does some further calculation with it, haven't checked fully how yet. But think about Michaelis and Menten enzyme kinetics we need to simplify it :) Just saying that a rate for an enzyme is given by v=dp/dt don't help :P

    • one year ago
  13. Frostbite
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    Or perhaps not simplify it, but get some veriables we can know.

    • one year ago
  14. gerryliyana
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    do you know how usually the value of translational constant, degradation rates of protein and etc?

    • one year ago
  15. Frostbite
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    To be honest: I have no idea, I could imagen that the degradation rate of a protein is determined by cell metabolism and the protein it self... as a matter of fact it could be anything.... think that kind of constants would be messured experimentally.

    • one year ago
  16. gerryliyana
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    ok..., thank you so much @Frostbite :)

    • one year ago
  17. Frostbite
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    Well I thank you too for the paper, it is intresting as a matter of fact.

    • one year ago
  18. Frostbite
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    I think that blues I linked to the question can provide so much more information about the subject than I. So hope blues comes and take a look.

    • one year ago
  19. blues
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    @gerryliyana , thank you for posting this very interesting article! And @Frostbite , thanks for notifying me of it. I will respond tomorrow when I have read the paper. Because the scope of the response depends somewhat on the scope of the question - single gene expression? whole cell expression? - I'd find more info on the question's context and background useful.

    • one year ago
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