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## gerryliyana 2 years ago What is the usefulness of MODELING GENE EXPRESSION ????

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1. gerryliyana

2. gerryliyana

Guys.., do you have any ideas??

3. Frostbite

Question: do I have to read it all?

4. gerryliyana

recommended :)

5. Frostbite

However the usefulness I can see as an important becuase if you want to do some kind of "gene kinetics" I see you use diffrential eqautions so you try to explain a change. Prob over time (without reading the full paper), this also give an idea of the flow of DNA replication mRNA translation and so on.

6. Frostbite

You could think like that... however for so big a system it most be a damn good model?

7. Frostbite

But what would you think?

8. Frostbite

And when it come to usefullness... well you can determine the flow of proteins? :)

9. Frostbite

@blues

10. gerryliyana

Thank you! :) .., How do I apply it ? for example, how to determine the value of protein concentration at any given time., ? and so on.,

11. Frostbite

Well that is the quite hard part... You need to read the artical part by part then, analyzing the equations and find out what values you may know for an example: $\frac{ dP }{ dt }=Lr-Up$ (equation 1) Might be a bit hard to use becuase we then need to know translational constants, mRNA concentrations, degradation rates of proteins and ofcause the protein concentration it self.

12. Frostbite

But I can see he does some further calculation with it, haven't checked fully how yet. But think about Michaelis and Menten enzyme kinetics we need to simplify it :) Just saying that a rate for an enzyme is given by v=dp/dt don't help :P

13. Frostbite

Or perhaps not simplify it, but get some veriables we can know.

14. gerryliyana

do you know how usually the value of translational constant, degradation rates of protein and etc?

15. Frostbite

To be honest: I have no idea, I could imagen that the degradation rate of a protein is determined by cell metabolism and the protein it self... as a matter of fact it could be anything.... think that kind of constants would be messured experimentally.

16. gerryliyana

ok..., thank you so much @Frostbite :)

17. Frostbite

Well I thank you too for the paper, it is intresting as a matter of fact.

18. Frostbite

I think that blues I linked to the question can provide so much more information about the subject than I. So hope blues comes and take a look.

19. blues

@gerryliyana , thank you for posting this very interesting article! And @Frostbite , thanks for notifying me of it. I will respond tomorrow when I have read the paper. Because the scope of the response depends somewhat on the scope of the question - single gene expression? whole cell expression? - I'd find more info on the question's context and background useful.

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