Could anyone tell me Effects of MDMA (3,4-methylenedioxy-N-methylamphetamine) Specifically on the nervous system.
Stacey Warren - Expert brainly.com
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What class is this really for...lol
Well first of all its an amphetamine meaning it heightens your nerves. An upper, high amounts of cause imbalance in brain Neuro transmitters. Which your brain also controls your central nervous system. Etc.
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The primary mode of action of MDMA is the enhanced release of 5-HT (Serotonin) by inhibiting the reuptake of 5-HT back into the presynaptic neuron. This enhanced release of 5-HT can be shown by the finding that 5-HT concentrations in brain tissue are markedly decreased during the first few hours following administration. An acute dose of MDMA can deplete 80% of central serotonin stores (Green, et. al., 1995).
In addition to its effects on serotonin, MDMA also causes increases in other neurotransmitters and neuromodulators such as dopamine, noradrenaline, acetylcholine, and histamine. MDMA has been called "neurochemically messy" because many of its neurochemical effects are interlinked. For example; the binding of (and subsequent activation of) 5-HT2a receptors by MDMA assists with the release of dopamine. Additionally any other drug that causes increases in cytosolic serotonin (either by synthesis of 5-HT- or by decreasing it's degradation) further enhance MDMA generated release of serotonin. .
Chronic or repeated MDMA exposure can damage serotonergic pathways in the brain. Though serotonin levels don't seem to be affected at the serotonergic pathway's initial structure (the raphe nucleus) there are decreases in 5-HT levels in the forebrain areas such as the cortex and hippocampus. These areas of the serotonergic pathways are pruned and and show a decreased number of serotonergic axons and terminals. This shows that MDMA initially stimulates the release of serotonin, but this acute stimulation is followed by a diminished serotonergic function..