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In most cases, nothing, though context and use of the term "hydrogen bomb" could change that. A nuclear bomb was called a hydrogen because it used hydrogen fusion. The intricacies between the first nuclear bomb and the design used today exist, however to the layman they can be considered one in the same.
Nuclear bombs produce their destructive power by nuclear reactions (fission and fusion) rather than chemical reactions. All hydrogen bombs are nuclear bombs, but not all nuclear bombs are hydrogen bombs. The first nuclear bombs derived their energy from fission of uranium or plutonium. Most so-called hydrogen bombs use a mixture of fusion (using lithium deuteride as the fuel) and fission stages; the fission stages are used to start the fusion reaction and use the extensive neutron flux produced by the fusion reaction to fission the casing which is made out of relatively plentiful U-238.
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