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-Pay no attention just marking this question so I can come back to it later.-
Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency. Gelsolin is located intracellularly (in cytosol and mitochondria) and extracellularly (in blood plasma)
Idk how it helps xD
it did help a little thnx:)
@abb0t help please
Yes, dwagonslaya has it correct. It is a protein. Hence, the suffix "in" usually indicates protein. As far as movement of the cell? What do you mean by that? Cells do not move, unless it is unicellular, such as an amoeba.
the amoeboid movement of cell along the substratum
I don't think this protein aids in any movement. It aids in making the mitochondrial membrane more permeable. That's all I know.
for eg during wound heling the cells crawl and occupy the spaces where the tearing of epithelium occurs.
I forgot to add that xD
I really do not know. I am not familiar with this protein. What course is this for? Maybe @aaronq may know?
The actin-binding protein gelsolin is involved in remodeling the actin cytoskeleton during growth-factor signaling, apoptosis, cytokinesis, and cell movement. Calcium-activated gelsolin severs and caps actin filaments. The 3.4 angstrom x-ray structure of the carboxyl-terminal half of gelsolin (G4-G6) in complex with actin reveals the basis for gelsolin activation. Calcium binding induces a conformational rearrangement in which domain G6 is flipped over and translated by about 40 angstroms relative to G4 and G5. The structural reorganization tears apart the continuous beta sheet core of G4 and G6. This exposes the actin-binding site on G4, enabling severing and capping of actin filaments to proceed.
Hope that helps!
i haven't come across this protein in my studies. But i can look into if you really need to know.
actually i was studying cytoskeletons. on which i have to give a presentation tomo. this is the part where i am stuck. @dwagonslaya420 ty.
ty u soooo much guys @aaronq @abb0t @dwagonslaya420 i finally found it in my book. pheww...:)
good stuff !
maybe post it here, so we can all know about it?
yes yes sure....give me 2 mins
Yes, I'll put it in my notes!
btw was I close to the answer? xD
for controlling actin polymerization there are actin binding proteins out of which gelsolin is one. during amoebid movement of cells the cytosol flows forward like a gel, this sol to gel transformation depends on assembly of new actin filaments in front part of moving cell and disassembly of old actin filament in rear part. this requires the assistance of severing protein gelsolin.
it is thought to break the actin filament and then it remains bound to the positive end of resulting fragment where it prevents addition or exchange of actin subunits. the negativ ends reapidly reduce. this causes disintegration in the rear part while the actin monomers get added to the positive end in the front part. this assists the movement of cells.
@dwagonslaya420 you were pretty close.
Dang I was like 2 sentences off I missed the 2-3 key points
yes...pretty close. good going @dwagonslaya420 :)
nice, thanks for the info.