I'm studying the reaction mechanism of polymerization (condensation), specifically from several amino acids (glycine) into a polypeptide. What is are the steps in this reaction mechanism?
*I've tried searching everywhere for it without luck.
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biosynthesis or chemical transformations?
Chemical transformations I think. Basically curly arrows and the transformation of electrons between atoms.
so you're using coupling reagents like DCC and NHS?
I can help you figure out the mechanism, i just need to know what reagents you're using.
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I'm not sure what the catalysts/conditions are, just the fact that several amino acids bond to form a polypeptide because of the attraction between the lone pair on nitrogen of one, and the slightly positive carbon atom on the other.
hmm okay, so this (attached) is the mechanism. I assumed this was biosynthesis (i.e. done by a ribosome, so i used tRNA to hold the amino acid, but you can replace it with another leaving group like NHS http://en.wikipedia.org/wiki/N-Hydroxysuccinimide)
you can also show the last step (proton transfer) by the negative O on the tRNA taking the proton from the \(-NH^+_2-\).