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rach_ell Group Title

I'm studying the reaction mechanism of polymerization (condensation), specifically from several amino acids (glycine) into a polypeptide. What is are the steps in this reaction mechanism? *I've tried searching everywhere for it without luck.

  • 9 months ago
  • 9 months ago

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  1. aaronq Group Title
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    biosynthesis or chemical transformations?

    • 9 months ago
  2. rach_ell Group Title
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    Chemical transformations I think. Basically curly arrows and the transformation of electrons between atoms.

    • 9 months ago
  3. aaronq Group Title
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    so you're using coupling reagents like DCC and NHS? I can help you figure out the mechanism, i just need to know what reagents you're using.

    • 9 months ago
  4. rach_ell Group Title
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    I'm not sure what the catalysts/conditions are, just the fact that several amino acids bond to form a polypeptide because of the attraction between the lone pair on nitrogen of one, and the slightly positive carbon atom on the other.

    • 9 months ago
  5. aaronq Group Title
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    hmm okay, so this (attached) is the mechanism. I assumed this was biosynthesis (i.e. done by a ribosome, so i used tRNA to hold the amino acid, but you can replace it with another leaving group like NHS http://en.wikipedia.org/wiki/N-Hydroxysuccinimide) you can also show the last step (proton transfer) by the negative O on the tRNA taking the proton from the \(-NH^+_2-\).

    • 9 months ago
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  6. rach_ell Group Title
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    How does the tRNA come in? I noticed in the diagram that it's drawn attached to one of the amino acids, but I'm slightly confused on where it came from and how it catalyzes the reaction

    • 9 months ago
  7. aaronq Group Title
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    we'll the catalysis would occur via the ribosome tRNA are mediator molecules for amino acids are to be recognized. i can redraw it using other reagents but i thought this would be less complicated.

    • 9 months ago
  8. rach_ell Group Title
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    I understand that part, just not why the tRNA is already bonded to the amino acid :/

    • 9 months ago
  9. aaronq Group Title
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    because that's how amino acids are brought to a ribosome during translation (you know, anticodon-codon recognition?).

    • 9 months ago
  10. rach_ell Group Title
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    Oh, we haven't learned that yet but I think I can work with the diagram. thanks!

    • 9 months ago
  11. aaronq Group Title
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    no problem, i hope thats sufficient. If you have doubts or want the mechanism with the other reagents, just ask.

    • 9 months ago
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