How do temperature, pH, enzyme concentration, and substrate concentration affect the rate of enzyme reactions?

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How do temperature, pH, enzyme concentration, and substrate concentration affect the rate of enzyme reactions?

Biology
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Wow, that is a freaking PhD dissertation right there. What level and how much detail are you expected?
Briefly, I would say that as temperature increases, the rate of reaction also increases, till a certain point where the enzyme then becomes denatured. In humans, this is above 38,39 Celsius, thus the dangers of a high fever. For pH, most enzymes operate over a small range of pH. Most would only operate around neutral so 7 but enzymes in the stomach operate at much lower pHs. If the pH goes out to the range, the rate of reaction would decrease. With enzymes concentration, the more concentrated, the faster the rate since there would be more available enzymes to convert the substrates. It would also increase the chances of collision. With substrate concentration, there would be an increased chance of collision and thus might be a little faster however, once the enzymes are all saturated (filled), the rate of reaction will level off.

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I'm only in Bio 1 but I have my final today and that was one of the review questions.
Shirley27, thank you so much!!

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