what is the role of Dna helicase during Dna replication ?

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what is the role of Dna helicase during Dna replication ?

Biology
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At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus. Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat.

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Hello! @sodacan333 ! Welcome to OpenStudy! Helicase is an enzyme that helps in the uncoiling of the DNA during its replication.

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During DNA replication the helicase actually separates the strands of DNA from each other by breaking the hydrogen bonds between base paris. @shreehari499 I would be cautious to say that the helicase uncoils the DNA as there are many levels of DNA coiling in the nucleus, and in this case we are specifically talking about the separation of the two strands. In fact enzymes such as topoisomerase, which change the level of DNA supercoiling actually make cuts in the DNA wherease the helicase does not (during replication).

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