When is an atom unlikely to react and form chemical bonds?

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When is an atom unlikely to react and form chemical bonds?

Physics
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At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus. Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat.

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When it has already lost so much energy and not anymore to loose...or you can say when its broke :P More the energy of the system more the instability if you understand the term del S or entropy of a system, then dont confuse more energy with more entropy, both are using different energies
when its valence shell is full This is why the Noble gasses are considered to be highly unreactive or to do not react easily to form chemical bonds
when it will stable that's simple thing to know .

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