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Wound healing is a metabolically heavy process. Cells involved in healing bone need a steady supply of nutrients and energy molecules, they generate a lot of waste and metabolites. Blood supplies nutrients and carries away cellular debris and waste. Less blood flow, slower healing.
Okay, that's good. But how about: Specifically describe how the drug would affect the three stages of bone healing.
he/she explained it good enough for you to get the effect on bone healing process though
try recalling the stages we can discuss more if you want
My only question left is what even are the three stages of bone healing? My lessons don't mention those, as usual, but feel compelled to ask a question about it.
oh i see can you use google sources or youtube? https://www.boundless.com/biology/textbooks/boundless-biology-textbook/the-musculoskeletal-system-38/bone-216/bone-remodeling-and-repair-819-12062/ I'd suggest to watch 3D animations on youtube also to get a better picture of the process
after you are done reading and if something is unclear, i will help you out
alright, thank you.
Okay, so how would I describe the second stage of bone generation? I got the first part done, I think, but that ones confuses me. @Somy
Bone generation: Within days of the fracture, capillaries grow into the hematoma, while phagocytic cells begin to clear away the dead cells. Though fragments of the blood clot may remain, fibroblasts and osteoblasts enter the area and begin to reform bone. Fibroblasts produce collagen fibers that connect the broken bone ends, while osteoblasts start to form spongy bone. The repair tissue between the broken bone ends, the fibrocartilaginous callus, is composed of both hyaline and fibrocartilage . Some bone spicules may also appear at this point. 1 - capillaries grow into hematoma = which means blood clot 2 - because there was bone fracture - there is a mess to clear up and that is the job done by phagocytic cells (the eating cells) for u to get a better idea, lets say you have a tube, made out of glass, now lets say you dropped it and it broke = this results in tiny pieces of glass scattered on the floor with bone its pretty much same except scattering degree is not much but still needs to be cleared up now its clean 3 - now you need to start building new bone and for that you need certain components, fibroblasts to produce collagen which is the matrix and major component of bone, osteoblast to produce bone itself now collagen that is produced by fibroblast is like a supporting structure that will connect the two ends of broken bone and support the structure look at this pic http://prntscr.com/9af2da in this construction, those long rods are basically collagen in our bones now once that is done we can go on with filling it with bone The repair tissue between the broken bone ends, the fibrocartilaginous callus, is composed of both hyaline and fibrocartilage . = callus is referred to the swelling thing in an area of healing, that swelling is basically the new matrix that is formed to start this process
All I'm understanding from any of the steps is that the process wouldn't even be able to BEGIN without the correct amount of blood flow through the vessels, but I still don't see what the rest of the steps need the blood vessels for. Maybe I just can't see it, I have been working on this exam all of today and half of yesterday.
okay look during this process the entire but MOSTLY the beginning of it you see a lot of activity and so that means you need a lot of nutrition and oxygen supply thus high blood supply levels if after fracture you take in a medication that reduces blood supply, you can still start the process but because of low supplies it will take longer to finish the entire process
https://www.youtube.com/watch?v=MNkI6Of2PRs watch this carefully, take notes if you need here he describes all the stages listen carefully to processes that occur in each stage depending on that you can say why you need blood flow in that particular stage